Sialic Acid a Marker of Diabetic Complication

BACKGROUND: The prevalence of diabetes is steadily increasing worldwide particularly in developing countries, it is associated with chronic complications which lead to considerable mortality and morbidity. Type II diabetes is considered as a disease of innate immune response, sialic acid represent as a marker of acute phase protein is found to be elevated in diabetic subjects. MATERIALS AND METHODS: A total of 104 type II diabetic cases were studied. Total serum sialic acid, glycated hemoglobin, lipid profile, urea, creatinine and 24 hrs urinary proteins were estimated in blood samples of both cases and controls. RESULT: Sialic acid, glycated hemoglobin, total protein, albumin and 24 hrs urinary protein concentrations are significantly higher in diabetics associated with complications compared to diabetic without any complications.SUMMARY AND CONCLUSION:ROC analysis showed that 24 hrs urinary protein, sialic acid are good marker for identification of Diabetic complications